DISP-13. FEMALE MICE HAVE GREATER SUSTAINED ACTIVITY SUPPRESSION AND HYPERSOMNOLENCE AFTER RADIATION THERAPY: EXPLORATION OF SEX DIFFERENCES IN A MODEL OF CRANIAL-RADIATION-INDUCED HYPERSOMNOLENCE (C-RIH)

Abstract Female cancer patients have a better prognosis but more adverse events with chemotherapy; less is known other treatments like radiation therapy. Previous literature has demonstrated sex-dependent effects on the hippocampi and behavioral tasks within post-natal mice after radiotherapy. We explored differences in activity sleep adult male female our previously established mouse model of cranial-irradiation-induced hypersomnolence (C-RIH). Ten each sex (B6 x B6D2 backcrossed C57/b6NCr) were observed for general continuously over 10 days before therapeutic irradiation (whole brain, 15Gy, single fraction). Behavioral assessments aimed at measuring anxiety (Light Dark Box, Elevated Zero Maze) depression (Sucrose Preference Test) related behaviors, working memory (Y then used to assess any radiation-induced changes mood or cognition. Independent samples t-tests compared cohorts radiation. At baseline, females had significantly higher peak (p < 0.001), as well day night = 0.004) activity. Females also showed Maze 0.001) Light-Dark Box 0.012). In Y-Maze, alternations (entry into arm without repeat) 0.004). Males consumed same proportion sucrose solution respect water 0.124). After radiation, males significant decrease activity, displaying suppression both 1-3 (t(18) 2.162, p 0.045) 7-9 2.266, 0.037). increased 4.474, 2.920, 0.01). Further analysis underway post-radiation Here we C-RIH outcomes between sexes found marked